Pic Courtesy: sciencedirect.com The Indian Diabetes Consortium (INDICO), a Pan-India initiative led by CSIR-Institute of Genomics and Integrative Biology (IGIB) with AIIMS as a principal clinical partner, has recently brought to light an entirely novel candidate gene, TMEM163 implicated in Type 2 Diabetes. TMEM163 encodes a probable vesicular transporter in nerve terminals; and the study established a plausible mechanism of action for TMEM163 through impaired insulin secretion. This lends an unprecedented ‘neural angle’ to diabetes that needs to be explored further and holds immense potential in understanding new pathogenetic mechanisms involved in diabetes causation The study currently accepted for publication in the ‘DIABETES’ (American Diabetes Association’s flagship journal), authored by 37 researchers, is the first and the largest ‘Genome Wide Association Study’ (GWAS) conducted for any complex disorder conceived and executed entirely in the developing world. The work inv
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